Database : HANSEN Search on : LINFOCITOS T [Subject descriptor] References found : 122 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 18227 Author: Quiroga, Maria F; Martinez, Gustavo J; Pasquinelli, Virginia; Costas, Monica A; Bracco, Maria M; Malbran, Aleajndro; Olivares, Liliana M; Sieling, Peter A; Garcia, Veronica E Title: Activation of signaling lymphocytic activation molecule triggers a signaling cascade that enhances Th1 responses in human intracellular infection ..- Source: s.l; s.n; 2004. 10 p. graf. Abstract: T cell production of IFN-gamma contributes to host defense against infections by intracellular pathogens, including mycobacteria. Lepromatous leprosy, the dissminated from of infection caused by Mycobacterium leprae, is characterized by loss of cellular response against the pathogen and diminished Th1 cytokine production. Relieving bacterial burden in Ag-unresponsive patients might be achieved through alternative receptors that stimulate IFN-gamma production. We have previously shown that ligation of signaling lymphocytic activation molecule (SLAM) enhances IFN-gamma in mycobacterial infection; therefore, we investigated molecular pathways leading from SLAM activation to IFN-gamma production in human leprosy. The expression of the SLAM-associated protein (an inhibitory factor for IFN-gamma induction) on M. leprae-stimulated cells from leprosy patients was inversely correlated to IFN-gamma production. Howevwe, SLAM ligation or exposure of cell from lepromatous patients to a proinflammatory microenvironment down-regulated SLAM-associated protein expression. Moreover. SALAM activation induced a sequence of signaling proteins, including activation of the NF-kB complex, phosphorylation of Stat1, and induction of T-bet expression, resulting in the promotion a cascade of molecular events during signaling through SLAM in leprosy that cooperate to induce INF-gamma production and strongly suggest that SLAM might be a focal point for therapeutic modulation of the cell cytokine responses in diseases characterized by dysfunctional Th2 responses (AU). Descriptors: HANSENIASE/imunol HANSENIASE/microbiol LINFOCITOS T/imunol LINFOCITOS T/microbiol INTERLEUCINAS/sangue INTERLEUCINAS/imunol - LINFOCITOS/imunol  LINFOCITOS/microbiol  MYCOBACTERIUM LEPRAE/imunol  MYCOBACTERIUM LEPRAE/patogen Limits: HUMANO Location: BR191.1; 09192/s

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Id: 13727 Author: Cheadle, Eleanor J; Selby, Peter J; Jackson, Andrew M Title: Mycobacterium bovis bacillus Calmette-Guérin-infected dendritic cells potently activate autologous T cells via a B7 and interleukin-12-dependent mechanism ..- Source: s.l; s.n; 2003. 10 p. graf. Abstract: Mycobacteria are potent adjuvants, can survive intracellularly and have been safely used for many years as vaccines against tuberculosis and leprosy. They are thus important potential vectors for recombinant vaccines. Many of their adjuvant properties are mediated following phagocytosis by dendritic cells (DC), which are in turn critical for priming naïve T cells. Although the maturation of DC in response to mycobacteria, such as Mycobacterium bovis bacillus Calmette-Guérin (BCG), is well described the subsequent responses of autologous T cells to mycobacterium-infected DC remains uncharacterized. In our experiments DC infected with BCG expressed more co-stimulatory molecules than tumour-necrosis factor-alpha (TNF-alpha) -treated DC and stimulated more potent mixed leucocyte reactions. When autologous T cells were co-cultured with BCG-exposed DC they became highly activated, as determined by display of CD25, CD54 and CD71 on both CD4+ and CD8+ cells. In contrast, the response of T cells to TNF-alpha-matured DC was significantly less. Cytokine production from T cells cultured with BCG-exposed DC was enhanced with elevated secretion of interleukin-2 (IL-2), IL-10 and interferon-gamma (IFN-gamma) and was produced by both CD4+ and CD8+ lymphocytes as determined by intracellular staining. In particular, IFN-gamma secretion was increased from 50 pg/ml to 25 000 pg/ml and IL-10 secretion increased from 20 pg/ml to 300 pg/ml in BCG-exposed DC co-cultures. Blocking antibodies to B7.1 and B7.2 or IL-12 significantly reduced the secretion of IFN-gamma and reductions were also seen in the expression of CD25 and CD71 by CD4+ cells. These data demonstrate that mycobacterially infected DC are particularly potent activators of autologous T cells compared to TNF-alpha-exposed DC and that the resultant T cells are functionally superior. (AU). Descriptors: ANTIGENOS CD/metab ANTIGENOS CD80/imunol ANTIGENOS DE DIFERENCIACAO DE LINFOCITOS B/metab LINFOCITOS T CD4-POSITIVOS/imunol LINFOCITOS T CD8-POSITIVOS/imunol CITOCINAS/bios CELULAS DENDRITICAS/imunol CELULAS DENDRITICAS/microbiol MOLECULA 1 DE ADESAO INTERCELULAR IMUNOFENOTIPAGEM INTERLEUCINA-12/imunol TRANSFORMACAO LINFOCITICA/imunol MYCOBACTERIUM BOVIS/imunol RECEPTORES DA INTERLEUCINA-2/metab LINFOCITOS T/imunol FATOR DE NECROSE TUMORAL/imunol REGULACAO PARA CIMA/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 08996/s

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Id: 13666 Author: Bala, Lakshmi; Anand, Sukumar; Sinha, Sudhir Title: Enhancement of human T cell response to a peptide epitope of 38kDa antigen of Mycobacterium tuberculosis by liposomes ..- Source: s.l; s.n; 2002. 9 p. graf. Abstract: Diagnosis of tuberculosis a problem, specially in the regions harboring an abundance of both pathogenic and non-pathogenic mycobacteria. This study was undertaken to assess in such a situation the predictive value of proliferative T cell response to a peptide epitope ('38G') of the 38 kDa membrane protein of Mycobacterium tuberculosis. 3[H]-thymidine incorporation assays were done with peripheral blood mononuclear cells of tuberculoid leprosy and pulmonary tuberculosis patients. The donors were also classified as PPD responders (Stimulation Index, SI> 3) or non-responders (SI < or = 3) on the basis of their T cell response to the 'Purified Protein Derivative (PPD)' of M. tuberculosis. 38G peptide was used in either free or liposome-associated form prepared by the technique of 'Dehydration-rehydration Vesicles' (Kirby and Gregoriadis, 1984). While free peptide failed to induce a positive response in study subjects, its liposomal form was T cell stimulatory and distinguished, to certain extent, between PPD responders (corresponding SI > 3 in 54 per cent subjects) and non-responders (SI > 3 in 29 per cent subjects). However, it did not differentiate between leprosy and tuberculosis. The study supports use of liposomes as adjuvant vehicles for antigenic peptides designed to activate human T cells. (AU). Descriptors: ANTIGENOS DE BACTERIAS/admin ANTIGENOS DE BACTERIAS/quim ANTIGENOS DE BACTERIAS/genet HANSENIASE TUBERCULOIDE/diag HANSENIASE TUBERCULOIDE/imunol EPITOPOS/admin EPITOPOS/quim EPITOPOS/genet DIAGNOSTICO DIFERENCIAL MYCOBACTERIUM TUBERCULOSIS/quim MYCOBACTERIUM TUBERCULOSIS/genet MYCOBACTERIUM TUBERCULOSIS/imunol DADOS DE SEQUÊNCIA MOLECULAR SEQUÊNCIA DE AMINOACIDOS LINFOCITOS T/imunol TESTE TUBERCULINICO TUBERCULOSE PULMONAR/diag TUBERCULOSE PULMONAR/imunol TRANSFORMACAO LINFOCITICA - LIPOSSOMOS  PESO MOLECULAR Limits: ESTUDO COMPARATIVO HUMANO IN VITRO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09061/s

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Id: 13585 Author: Bjune, Gunnar Title: Significance of immune reactions in leprosy ..- Source: s.l; s.n; Jun-Jul. 1980. 20 p. . Abstract: The disease Leprosy is a chronic infectious disease caused by Mycobacterium leprae. The only known natural host for this mycobacterium is the human being. A mycobacterial disease described in wild armadillos in Louisiana as being indistinguishable from leprosy (walsh et al. 1975), is of questionable significance for the epidemiology in humans (Fillice et al. 1977).(AU). Descriptors: IMUNOSSUPRESSAO TECNICAS IMUNOLOGICAS LINFOCITOS T/imunol ERITEMA NODOSO/imunol HANSENIASE/genet HANSENIASE/imunol HANSENIASE/microbiol MYCOBACTERIUM LEPRAE/cresc Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00262/s

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Id: 13562 Author: Turk, J. L Title: Leprosy as a model of subacute and chronic immunologic diseases ..- Source: s.l; s.n; sep. 1976. 7 p. ilus, tab. Abstract: One of the major problems in the investigation of the possible immunologic basis for certain skin diseases is that in most cases it has not been possible to define the etiologic factors with any degree of precision.(AU). Descriptors: GRANULOMA/imunol ERITEMA NODOSO/imunol HANSENIASE/clas HANSENIASE/imunol HANSENIASE/patol SIFILIS/imunol LINFOCITOS T/imunol LINFOCITOS T/patol Limits: HUMANO ANIMAL CAMUNDONGOS Electronic Medium: http://www.ilsl.br Location: BR191.1; 00030/s

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Id: 13552 Author: Freiberger, Harley F; Fudenberg, H. Hugh Title: An appetite for armadillo ..- Source: s.l; s.n; jun. 1981. 8 p. ilus. Abstract: In October 1979, a 70-year-old man was referred and admitted to the Medical University of South Carolina Hospital. Three or four years earlier, he had begun to notice the appearance of raised, nontender lumps on his arms and legs.(AU). Descriptors: DOENCAS DO COMPLEXO IMUNE/imunol IMUNIDADE CELULAR HANSENIASE/imunol PLASMAFERESE LINFOCITOS T/imunol Limits: RELATO DE CASO HUMANO MASCULINO IDOSO Electronic Medium: http://www.ilsl.br Location: BR191.1; 01472/s

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Id: 13536 Author: Nath, Indira; Curtis, Jill; Bhutani, L. K; Talwar, G. P Title: Reduction of subpopulation of T lymphocytes in lepromatous leprosy ..- Source: s.l; s.n; 1974. 7 p. tab, graf. Abstract: A reduction in number of a subpopulation of T lymphocytes was noted in lepromatous leprosy cases with high bacillary load. Tuberculoid and treated lepromatous patients, who were bacillary negative had normal levels of these cells. B-cell numbers were high in lepromatous patients of treatment and bacillary load. (AU). Descriptors: REACAO DE IMUNO-ADERÊNCIA HANSENIASE/compl HANSENIASE/imunol HANSENIASE/microbiol LINFOCITOS T/imunol FATORES DE TEMPO CONTAGEM DE LEUCOCITOS TUBERCULOSE/compl LINFOCITOS B Limits: HUMANO Location: BR191.1; 03163/s

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Id: 13501 Author: Haregewoin, Abebe; Godal, Tore; Mustafa, Abu Salim; Belehu, Ayele; Yemaneberhan, Tabebe Title: T-cell conditioned media reverse T-cell unresponsiveness in lepromatous leprosy ..- Source: s.l; s.n; May 26, 1983. 3 p. . Abstract: In some subjects the infective agent of leprosy, Mycobacterium leprae, causes disseminated (lepromatous) disease. Such subjects have a major role in the transmission of the disease and show deficient T-cell responses both in vivo and in vitro to M. leprae, but not to other antigens. Numerous studies have recently shown that T cells with functional capabilities after initial triggering with antigen can be maintained in a state of continuous proliferation in vitro when cultured in medium containing interleukin 2 (IL-2). Here we have studied the effect of IL-2 rich T-cell conditioned medium on lepromatous peripheral blood mononuclear cells. Our results show that although lepromatous T cells fail to produce IL-2 after exposure to M. leprae they can respond by proliferation to M. leprae in the presence of T-cell conditioned medium, suggesting that the unresponsiveness in lepromatous leprosy results from a deficiency in the production of IL-2 or related factors and not a lack of M. leprae-reactive T cells.(AU). Descriptors: MEIOS DE CULTURA TOLERÂNCIA IMUNOLOGICA INTERLEUCINA-2/imunol HANSENIASE/imunol TRANSFORMACAO LINFOCITICA LINFOCITOS T/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01401/s

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Id: 13486 Author: Roselle, G. A; Kauffman, C. A Title: Amphotericin B and 5-fluorocytosine: effects on cell-mediated immunity ..- Source: s.l; s.n; apr. 1980. 7 p. tab, graf. Abstract: Although single-dose amphotericin B therapy appears to be immunostimulatory in mice, no data are available regarding the effects of chronic anti-fungal drug therapy on the immune system. We studied the effects on the guinea-pig cellular immune system of 4 weeks of treatment with amphotericin B, 5-fluorocytosine, or the combination of both drugs. The in vitro lymphocyte response to phytohaemagglutinin and the specific antigen, picryl human serum albumin (picHSA), were not affected by anti-fungal drug treatment. At 1.5 weeks of therapy with amphotericin B, skin test reactivity to picHSA was significantly reduced but returned toward normal by the end of 3.5 weeks of drug therapy. Macrophage migration inhibitory factor production by guinea-pig peripheral blood lymphocytes was significantly reduced after 4 weeks of amphotericin B therapy. No immunostimulatory properties could be ascribed to amphotericin B. 5-fluorocytosine had no effect on cellular immunity.(AU). Descriptors: TESTES CUTÂNEOS FATORES INIBIDORES DA MIGRACAO DE MACROFAGOS/anal CONTAGEM DE LEUCOCITOS LINFOCITOS T/imunol IMUNIDADE CELULAR/ef drogas TRANSFORMACAO LINFOCITICA/ef drogas FLUCITOSINA/farmacol CITOSINA/analog ANFOTERICINA B/farmacol Limits: ANIMAL FEMININO COBAIAS SUPPORT, U.S. GOV'T, NON-P.H.S. Electronic Medium: http://www.ilsl.br Location: BR191.1; 01306/s

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Id: 13462 Author: Bach, Marie Anne; Chatenoud, Lucienne; Wallach, D; Phan Dinh Tuy, Françoise; Cottenot, F Title: Studies on T cell subsets and functions in leprosy ..- Source: s.l; s.n; jun. 1981. 10 p. tab, graf. Abstract: T cell subsets and T cell functions were explored in 31 leprosy patients with the following methods: determination of the percentages of the different T cell subpopulations defined by monoclonal antibodies directed at total T cells, helper T cells and suppressor/cytotoxic T cells; measurement of the in vitro proliferative responses to mitogens; study of the concanavalin A-induced suppressive activity, assessed on MLC; measurement of delayed-type hypersensitivity by skin testing. The confrontation between immunological lepromatous patients without type-2 reaction (erythema nodosum leprosum), (2) lepromatous patients without ENL (erythema nodosum leprosum), (2) lepromatous patients was recent ENL and (3) tuberculoid patients. Unexpectedly, groups 1 and 3, although differing strongly in their clinical status and their sensitivity to lepromin (absent in group 1 and strong in group 3), showed a similar immunological profile with a normal percentage of T cells and a normal distribution of T cells among the major T cell subset contrasting with a moderate decrease of proliferative responses to mitogens and impaired delayed-type hypersensitivity reactions. Concanavalin A-induced suppressive activity was type-2 reaction) strongly differed from both other groups, showing striking abnormalities other groups, showing striking abnormalities of the repartition of the T cell subsets, with increased percentages of helper T cells and decreased percentages of suppressor T cells, and elevated proliferative responses to mitogens. Concanavalin A-induced suppressive activity was reduced in most patients of this group. It is suggested that this imbalance between T cell subsets contributes to the occurrence of ENL reactions in lepromatous patients.(AU). Descriptors: ANTICORPOS MONOCLONAIS/imunol HANSENIASE/imunol TESTES INTRADERMICOS CONTAGEM DE LEUCOCITOS TRANSFORMACAO LINFOCITICA LINFOCITOS T/clas LINFOCITOS T/imunol LINFOCITOS T SUPRESSORES-EFETORES/imunol CONCANAVALINA A/farmacol Limits: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE IDOSO SUPPORT, NON-U.S. GOV'T ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 01450/s

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Id: 13450 Author: Modlin, Robert L; Hofman, Florence M; Horwitz, David A; Husmann, Linda A; Gillis, Steven; Taylor, Clive R; Rea, Thomas H Title: In situ identification of cells in human leprosy granulomas with monoclonal antibodies to interleukin 2 and its receptor ..- Source: s.l; s.n; Jun. 1984. 6 p. ilus, tab, graf. Abstract: Leprosy is a chronic granulomatous disease with an immunologic spectrum in which lepromatous leprosy patients have defective cell-mediated immune responses, in comparison to tuberculoid leprosy patients. Immunoregulatory aspects of this spectrum were investigated by using monoclonal antibodies to interleukin 2 (IL 2), IL 2 receptors (Tac), and T lymphocyte subpopulations with immunoperoxidase techniques on frozen sections of skin biopsy specimens from 10 tuberculoid and 10 lepromatous patients. A comparison of IL 2+ cells revealed markedly fewer IL 2+ cells in lepromatous specimens (lep. 0.028% +/- 0.02 vs tub. 0.46% +/- 0.28, p less than 0.001). These IL 2+ cells were large, exhibited cytoplasmic staining, and on double immunostaining were Leu-4+, Leu-3a+, Leu-2a-, Tac-, and OKT6-, consistent with the fact they are IL 2 producers. Equivalent numbers of Tac+ cells were observed in both lepromatous and tuberculoid granulomas (lep. 1.5% +/- 0.5 vs tub. 2.1% +/- 0.7, p, NS), suggesting that the responder cells are present in both conditions. The tuberculoid granuloma was highly organized, composed of a central core of mature macrophages, Leu-3a+ and Tac+ cells with a surrounding mantle of Leu-2a+, Leu-3a+, IL 2+, Tac+, and OKT6+ cells. In lepromatous granulomas, Leu-2a+, Leu-3a+, Tac+, and rare IL 2+ cells were randomly admixed with bacilli-laden macrophages. The defective cell-mediated immune responses in lepromatous leprosy appears to be associated with diminished IL 2 production and disorganization of the granuloma.(AU). Descriptors: GRANULOMA/imunol GRANULOMA/metab HISTOCITOQUIMICA INTERLEUCINA-2/bios INTERLEUCINA-2/imunol HANSENIASE/imunol HANSENIASE/metab LINFOCITOS T/clas LINFOCITOS T/imunol LINFOCITOS T/metab Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01415/s

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Id: 13428 Author: Modlin, R. L; Gebhard, J. F; Taylor, C. R; Rea, T. H Title: In situ characterization of T lymphocyte subsets in the reactional states of leprosy ..- Source: s.l; s.n; jul. 1983. 8 p. ilus, tab. Abstract: Using monoclonal antibodies and the immunoperoxidase technique, the numbers and distribution of T lymphocyte subsets in the tissues of reactional states of leprosy (six reversal reaction, nine erythema nodosum leprosum (ENL) and two Lucio's reaction) were determined and compared with those found in stable, non-reactional patients (six tuberculoid, two borderline lepromatous and seven lepromatous). The pattern of segregation of the suppressor/cytotoxic phenotype at the periphery of the granuloma was found in both non-reactional tuberculoid lesions and reversal reactions, but was better developed in the former. In ENL and Lucio's reaction, as well as in non-reactional lepromatous tissue, the helper/inducer and suppressor/cytotoxic phenotypes were both admixed with the aggregated histiocytes. However, the helper/suppressor ratio in ENL (2.1 +/- 0.4) was significantly larger than that in non-reactional lepromatous tissue (0.7 +/- 0.4, P less than 0.001). The immature thymocyte antigen OKT6 was found on scattered large non-lymphoid cells, most commonly in tuberculoid and reversal reaction tissues, less commonly in ENL, but only irregularly in non-reactional lepromatous tissue. The peripheral pattern of the suppressor/cytotoxic phenotype may be an immunohistological reflection of a cell-mediated immune response common to both non-reactional tuberculoid and reversal reaction patients. The reversal of the helper/suppressor ratio in ENL as compared to non-reactional lepromatous disease suggests some role for cell-mediated immunity in the pathogenesis of ENL. The OKT6 positive cell is of unknown origin and function.(AU). Descriptors: PELE/patol CONTAGEM DE LEUCOCITOS HANSENIASE/imunol HANSENIASE/patol TECNICAS IMUNOENZIMATICAS LINFOCITOS T/imunol ERITEMA NODOSO/patol LINFOCITOS T AUXILIADORES-INDUTORES/imunol LINFOCITOS T SUPRESSORES-EFETORES/imunol ANTICORPOS MONOCLONAIS/imunol Limits: ESTUDO COMPARATIVO HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01386/s

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Id: 13425 Author: Narayanan, R. B; Bhutani, L. K; Sharma, A. K; Nath, I Title: T cell subsets in leprosy lesions: in situ characterization using monoclonal antibodies ..- Source: s.l; s.n; mar. 1983. 9 p. ilus, tab. Abstract: Cryostat sections of dermal lesions from 30 untreated leprosy patients were studied by indirect immunofluorescence using monoclonal antibodies defining T cell subsets and Ia like antigens. Most lymphocytes in leprosy lesions were positive for OKT3 and Ia like antigens indicating thereby the presence of activated T cells. Maximal numbers of these cells were seen in localized paucibacillary tuberculoid leprosy lesions in close association with epithelioid cells. A decline in their numbers was observed over the leprosy spectrum with a marked reduction in disseminated, multi-bacillary, lepromatous leprosy where only scattered OKT3+ cells were visualized. OKT4 and OKT8 positive cells defining T cell subsets, were frequently found within the OKT3+ lymphocytes throughout the leprosy spectrum. The ratio of OKT4+/OKT8+ cells ranged from 1.2 to 5.0 in tuberculoid and from 0.2 to 1.0 in lepromatous lesions. Macrophages in the granulomas stained intensely with anti-Ia antisera. Ia like antigens were expressed to the same degree on macrophages with or without intracellular acid fast bacilli.(AU). Descriptors: GRANULOMA/imunol GRANULOMA/patol CONTAGEM DE LEUCOCITOS PELE/imunol PELE/patol HANSENIASE/imunol HANSENIASE/patol LINFOCITOS T/clas LINFOCITOS T/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01382/s

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Id: 13329 Author: Salgame, Padmini R; Mahadevan, P. R; Antia, Noshir H Title: Mechanism of immunosuppression in leprosy: presence of suppressor factor(s) from macrophages of lepromatous patients ..- Source: s.l; s.n; jun. 1983. 8 p. tab, graf. Abstract: Human peripheral blood mononuclear cell proliferation induced by Mycobacterium leprae could...(AU). Descriptors: HANSENIASE/imunol LINFOCINAS/anal LINFOCINAS/farmacol FATORES INIBIDORES DA MIGRACAO DE MACROFAGOS/antag FATORES INIBIDORES DA MIGRACAO DE MACROFAGOS/anal FATORES INIBIDORES DA MIGRACAO DE MACROFAGOS/farmacol MYCOBACTERIUM LEPRAE/imunol LINFOCITOS T/imunol LINFOCITOS T SUPRESSORES-EFETORES/imunol - CONCANAVALINA A/farmacol  TOLERÂNCIA IMUNOLOGICA  TRANSFORMACAO LINFOCITICA  MACROFAGOS/imunol  MYCOBACTERIUM/imunol  FATORES SUPRESSORES IMUNOLOGICOS  FATORES DE TEMPO Electronic Medium: http://www.ilsl.br Location: BR191.1; 01218/s

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Id: 13324 Author: Rea, T. H; Quismorio, F. P; Harding, B; Nies, K. M; Di Saia, P. J; Levan NE;; Friou GJ Title: Immunologic responses in patients with lepromatous leprosy ..- Source: s.l; s.n; jun. 1976. 10 p. tab, graf. Abstract: Immunologic responses were measured in 46 patients with lepromatous leprosy. These patients were not distinguishable from controls on the basis of responses to soluble intradermal antigens, sensitization to contactants, peripheral blood T- and B-cell percentages, in vitro lymphocyte responses to a mitogen, or the prevalence of autoantibodies. Generalized immunologic abnormalities in patients with lepromatous leprosy are neither predisposing causes nor necessary accompaniments of lepromatous leprosy, but are probably remote sequellae of the illness. By implication, the generalized immunologic abnormalities reported in other diseases are likely to be remote sequellae of the particular illness.(AU). Descriptors: DERMATITE ATOPICA/ind quim DERMATITE DE CONTATO/etiol LECTINAS/farmacol ANTIGENO DE MITSUDA/farmacol HANSENIASE/clas HANSENIASE/genet HANSENIASE/imunol PELE/imunol LINFOCITOS T/imunol - DINITROCLOROBENZENO  DINITROFLUOROBENZENO  ANTIGENOS  AUTO-ANTICORPOS  LINFOCITOS B/imunol  CONTAGEM DE LEUCOCITOS  TRANSFORMACAO LINFOCITICA Limits: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE IDOSO Electronic Medium: http://www.ilsl.br Location: BR191.1; 01265/s

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Id: 13315 Author: Haregewoin, Abebe; Godal, Tore; Mustafa, Abu Salim; Belehu, Ayele; Yemaneberhan, Tabebe Title: T-cell conditioned media reverse T-cell unresponsiveness in lepromatous leprosy ..- Source: s.l; s.n; may 1983. 3 p. ilus, tab. Abstract: In some subjects the infective agent of leprosy, Mycobacterium leprae, causes disseminated (lepromatous) disease. Such subjects have a major role in the transmission of the disease and show deficient T-cell responses both in vivo and in vitro to M. leprae, but not to other antigens. Numerous studies have recently shown that T cells with functional capabilities after initial triggering with antigen can be maintained in a state of continuous proliferation in vitro when cultured in medium containing interleukin 2 (IL-2). Here we have studied the effect of IL-2 rich T-cell conditioned medium on lepromatous peripheral blood mononuclear cells. Our results show that although lepromatous T cells fail to produce IL-2 after exposure to M. leprae they can respond by proliferation to M. leprae in the presence of T-cell conditioned medium, suggesting that the unresponsiveness in lepromatous leprosy results from a deficiency in the production of IL-2 or related factors and not a lack of M. leprae-reactive T cells.(AU). Descriptors: MEIOS DE CULTURA TOLERÂNCIA IMUNOLOGICA INTERLEUCINA-2/imunol HANSENIASE/imunol LINFOCITOS T/imunol - TRANSFORMACAO LINFOCITICA Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01176/s

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Id: 13282 Author: Hirschberg, H Title: The role of macrophages in the lymphoproliferative response to mycobacterium leprae in vitro ..- Source: s.l; s.n; oct. 1978. 6 p. tab. Abstract: Peripheral blood lymphocytes from patients suffering from lepromatous leprosy do not normally react in vitro stimulation by Mycobacterium leprae antigens. In contrast, we found that T cells from non-responding patients in combination with macrophages from responding patients or healthy contacts did respond well to M. leprae. Conversely, T cells from responding patients or healthy contacts in combinations with macrophages from non-responding patients failed to respond. I seems, therefore, that the lack of response normally observed in in vitro tests using cells from lepromatous leprosy patients is due to a failure of their macrophages to present M. leprae antigens is an immunogenic form.(AU). Descriptors: ANTIGENOS DE BACTERIAS/imunol HANSENIASE/imunol TRANSFORMACAO LINFOCITICA COOPERACAO LINFOCITICA MACROFAGOS/imunol MYCOBACTERIUM LEPRAE/imunol LINFOCITOS T/imunol Limits: HUMANO Electronic Medium: http://www.ilsl.br Location: BR191.1; 00541

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Id: 13268 Author: Bach, Marie-Anne; Chatenoud, Lucienne; Wallach, D; Phan Dinh Tuy, F; Cottenot, F Title: Studies on T cell subsets and functions in leprosy ..- Source: s.l; s.n; jun. 1981. 10 p. tab, graf. Abstract: T cell subsets and T cell functions were explored in 31 leprosy patients with the following methods: determination of the percentages of the different T cell subpopulations defined by monoclonal antibodies directed at total T cells, helper T cells and suppressor/cytotoxic T cells; measurement of the in vitro proliferative responses to mitogens; study of the concanavalin A-induced suppressive activity, assessed on MLC; measurement of delayed-type hypersensitivity by skin testing. The confrontation between immunological lepromatous patients without type-2 reaction (erythema nodosum leprosum), (2) lepromatous patients without ENL (erythema nodosum leprosum), (2) lepromatous patients was recent ENL and (3) tuberculoid patients. Unexpectedly, groups 1 and 3, although differing strongly in their clinical status and their sensitivity to lepromin (absent in group 1 and strong in group 3), showed a similar immunological profile with a normal percentage of T cells and a normal distribution of T cells among the major T cell subset contrasting with a moderate decrease of proliferative responses to mitogens and impaired delayed-type hypersensitivity reactions. Concanavalin A-induced suppressive activity was type-2 reaction) strongly differed from both other groups, showing striking abnormalities other groups, showing striking abnormalities of the repartition of the T cell subsets, with increased percentages of helper T cells and decreased percentages of suppressor T cells, and elevated proliferative responses to mitogens. Concanavalin A-induced suppressive activity was reduced in most patients of this group. It is suggested that this imbalance between T cell subsets contributes to the occurrence of ENL reactions in lepromatous patients.(AU). Descriptors: ANTICORPOS MONOCLONAIS/imunol CONCANAVALINA A/farmacol TESTES INTRADERMICOS HANSENIASE/imunol CONTAGEM DE LEUCOCITOS TRANSFORMACAO LINFOCITICA LINFOCITOS T/clas LINFOCITOS T/imunol LINFOCITOS T SUPRESSORES-EFETORES/imunol Limits: HUMANO MASCULINO FEMININO ADULTO MEIA-IDADE IDOSO SUPPORT, NON-U.S. GOV'T ADOLESCENTE Electronic Medium: http://www.ilsl.br Location: BR191.1; 01569/s

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Id: 13267 Author: Modlin, R. L; Hofman, F. M; Meyer, P. R; Sharma, O. P; Taylor, C. R; Rea, T. H Title: In situ demonstration of T lymphocyte subsets in granulomatous inflammation: leprosy, rhinoscleroma and sarcoidosis ..- Source: s.l; s.n; mar. 1983. 9 p. ilus. Abstract: T lymphocyte subpopulations in frozen tissue sections of four granulomatous conditions (five patients with tuberculoid leprosy, five with lepromatous leprosy, seven with sarcoidosis and four with rhinoscleroma) were studied using monoclonal antibodies and a modified immunoperoxidase technique. Two immunohistological patterns were observed. In tuberculoid leprosy and sarcoidosis, lymphocytes expressing the helper/inducer phenotype were present within the aggregates of mononuclear phagocytes (epithelioid cells); however, cells with the suppressor/cytotoxic phenotype were predominantly in the lymphocytic mantle surrounding each granuloma. In lepromatous leprosy and rhinoscleroma the helper/inducer T cells and suppressor/cytotoxic T cells were both diffusely distributed among the mononuclear phagocytes (histiocytes) without any discernible mantle. The segregation of the helper/inducer and suppressor/cytotoxic phenotypic subsets was associated with an epithelioid cell differentiation of mononuclear phagocytic cells, bacterial elimination and a delayed type hypersensitivity response. The intimate admixture of helper/inducer and suppressor/cytotoxic subsets was associated with undifferentiated mononuclear phagocytes, bacterial proliferation and the absence of a delayed type hypersensitivity response. Thus the different distributions of T cell subpopulations in granulomas may be associated with differences in the host's immune response in several forms of granulomatous reactions.(AU). Descriptors: LINFOCITOS T/imunol LINFOCITOS T AUXILIADORES-INDUTORES/imunol GRANULOMA/imunol HANSENIASE/imunol HANSENIASE/patol CONTAGEM DE LEUCOCITOS RINOSCLEROMA/imunol RINOSCLEROMA/patol PELE/imunol PELE/patol Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 01381/s

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Id: 13265 Author: Bahr, G. M; Rook, G. A; Moreno, E; Lydyard, P. M; Modabber, F. Z; Stanford, J. L Title: Use of the ELISA to screen for anti-thymocyte and anti-beta 2-microglobulin antibodies in leprosy and SLE ..- Source: s.l; s.n; dec. 1980. 9 p. graf. Abstract: A report is given of the use of the enzyme-linked immunosorbent assay to measure antibody to preparations of human thymocyte membranes (HTMA) and to beta 2-microglobulin. The assay described is simple and rapid, and requires only small quantities of an easily stored membrane preparation. The advantages of this technique over conventional methods involving cytotoxicity are discussed. Raised levels of IgM antibody to beta 2-microglobulin were detected in sera from SLE patients. Raised levels of IgG and IgM antibody to HTMA were found in sera from most active lepromatous cases. Two of eight sera from SLE patients showed raised IgG anti-HMTA, but not raised IgM. An attempt was made to study the subclass of the IgG antibodies found, but when checked against purified human IgG myeloma proteins, the available anti-subclass sera were found to lack the necessary degree of specificity in this assay. (AU). Descriptors: AUTO-ANTICORPOS/anal BETA-GLOBULINAS/imunol ELISA IMUNOGLOBULINA G/anal IMUNOGLOBULINA G/clas IMUNOGLOBULINA M/anal HANSENIASE/imunol LUPUS ERITEMATOSO SISTÊMICO/imunol LINFOCITOS T/imunol MICROGLOBULINA-2 BETA/imunol Limits: HUMANO SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 0713/s

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